Prasanna Balaprakash
Entrepreneur & AI+HPC Research Leader

Prasanna Balaprakash

Co-founder & CEO at PrimaLabs, building next-generation hardware, application, cost -aware enterprise AI solutions. Former Director of AI and Distinguished R&D Scientist at Oak Ridge National Laboratory and Group Leader at Argonne National Laboratory, where I directed breakthrough research at the intersection of AI and high-performance computing.

Track Record

Two decades of experience leading AI research and development at the world's most advanced computing facilities. I bridge fundamental research and real-world deployment, from training trillion-parameter models on exascale supercomputers to building optimization platforms used across government, industry, and academia. Led research efforts at Oak Ridge in launching transformational mode consortium (ModCon), which is a basis for DOE Genesis Mission to accelerate science through AI.

Breakthrough Projects

Exascale AI Training

Directed the first trillion-parameter AI model training on Frontier, the world's fastest supercomputer. Achieved 87% GPU efficiency on AMD MI250X hardware—proving capability to scale foundation models beyond industry standard limits across 49,152 GPUs.

ORBIT Foundation Model

Directed the development of a 113-billion parameter Vision Transformer for climate modeling. Surpassed previous climate AI models by 1,000x in scale, achieving 1.6 exaFLOPS sustained throughput. ACM Gordon Bell Prize Finalist (2024, 2025).

DeepHyper Platform

Created DeepHyper, a scalable AutoML framework for neural architecture and hyperparameter search. Powers AI optimization across national laboratories, enabling 10x faster deployment on new hardware platforms.

Graph Foundation Models

Pioneered large-scale graph foundation models for atomistic materials modeling on 5.2TB of materials data. Achieved near-linear scaling using 16,000+ GPUs, advancing AI-driven materials discovery.

Hardware Co-Optimization

Developed ytopt, a hardware-aware optimization toolkit that automates performance tuning across diverse computing architectures.

AI for Climate Science

Built hybrid climate modeling systems using AI-assisted process emulators. Demonstrated long-range weather prediction capabilities that bring operational forecasting within reach for extreme weather events.

Industry Collaboration

Established strategic partnerships that accelerated AI innovation and provided early access to next-generation platforms.

AMD Optimized complete software stack for enterprise AI workloads
NVIDIA Advanced DGX deployment and model compression pipelines
Microsoft DeepSpeed collaboration to accelerate scientific discovery
Google Strategic R&D partnerships for AI model development

Strategic Impact

ORNL AI Initiative Director

Led ORNL's $8M/year AI Initiative (lab's largest cross-cut LDRD investment), managing 50+ researchers across 10+ advanced AI projects. Restructured the initiative to prioritize secure, trustworthy, and energy-efficient AI for scientific discovery and national security.

Section Head, Data & AI Systems

Provided strategic leadership for 45 researchers across five groups specializing in AI/ML, visualization, data workflows, and performance systems. Shaped divisional research directions through team building and resource alignment.

Policy & Advisory

Member of Tennessee AI Advisory Council (Governor-appointed). Invited participant at White House roundtables on AI R&D. Delivered briefings to U.S. Senate and House staffers on AI strategy and supercomputing.

Program Development

Obtained over $20M+ in direct funding and helped secure over $200M+ in total funding across 44 competitively reviewed proposals (33 external, 11 internal). This substantial financial support has played a pivotal role in advancing research and development across AI, machine learning, high-performance computing, and scientific applications.

44
Funded Proposals
$20M+
Direct Funding
$200M+
Total Portfolio

Awards & Fellowships

Best Paper Awards SC (2025), IEEE eScience (2023)
Gordon Bell Prize Finalist 2024, 2025 — ORBIT Climate Foundation Models
R&D 100 Award Winner 2025 — PRESTO Privacy Optimization
R&D 100 Award Finalist 2024 — DeepHyper AutoML Framework
HPCWire Editor's Choice 2024 — Top Supercomputing Achievement
DOE Early Career Award 2018 — $2.5M over 5 years
Marie Curie Fellowship 2004-2006 — European Commission
F.N.R.S. Fellowship 2006-2008 — Belgian Scientific Research

Research & Dissemination

57
Journal Articles
77
Conference Papers
24
Invited Talks
84
Presentations

Two decades of contributions spanning AI/ML systems, high-performance computing, and scientific applications. Research published in top-tier venues including SC, NeurIPS, ICML, Nature journals, and domain-specific conferences. View complete publication list on Google Scholar → | Download full CV for details →

Professional Journey

2025 – Present
Co-founder & CEO, PrimaLabs
Building enterprise AI optimization platform
2023 – 2025
Director of AI Programs, Oak Ridge National Laboratory
Led $8M/year AI Initiative, 50+ researchers, secured $40M+/year in ROI
2025
Section Head, Data & AI Systems Research, Oak Ridge National Laboratory
Strategic leadership for 45 researchers across five technical groups
2013 – 2023
Computer Scientist & Group Leader, Argonne National Laboratory
Developed DeepHyper, ytopt, and pioneered AutoML for scientific computing
2012 – 2015
Co-founder & CTO, inSiliTech LLC
Launched startup from Chicago Booth's New Venture Challenge, developed AI-driven computational tools
2010 – 2013
Postdoctoral Researcher, Argonne National Laboratory
Advanced research in optimization and machine learning for HPC
2009 – 2010
Chief Technology Officer, Mentis Consulting
Led technology strategy and development for consulting firm in Brussels, Belgium
2010
PhD in Engineering Sciences, Université libre de Bruxelles
Focus: Automated tuning, swarm intelligence, stochastic combinatorial optimization